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Causes of Female Infertility

While diagnosing and treating male infertility is often relatively straightforward, the causes of female infertility vary widely and can be complex. Keep in mind that in many cases there are multiple causes for infertility. The most commons ones are described here.

Blockage of fallopian tubes: When a fallopian tube is blocked it prevents eggs from traveling from the ovary to the uterus. A blocked or damaged fallopian tube can be caused by scarring, endometriosis, prior surgery, pelvic adhesions, or tubal pregnancy. Pelvic inflammatory disease (PID) is a common cause of tube damage and a major contributor to infertility. Fortunately, blocked fallopian tubes can often be treated surgically, or bypassed with IVF.    

Endometriosis: Another common cause of infertility, endometriosis, is where a woman has endometrial tissue (normal uterus lining tissue) outside the uterine cavity.  This can cause scarring around the fallopian tubes and ovaries, making conception less likely.  However, not all women with endometriosis have problems getting pregnant. Endometriosis may be diagnosed and treated with laparoscopic surgery.  

Polycystic ovary syndrome (PCOS): This is a hormonal disorder that causes irregular menstrual cycles and less frequent ovulation. PCOS may be treated with fertility drugs.

Article: Update on Polycystic Ovary Syndrome (PCOS)

Premature ovarian failure (POF): This is the loss of ovarian function in women under the age of forty. POF is diagnosed by testing certain hormone levels in the blood. POF may be treated with medications intended to stimulate the ovaries to produce and release eggs.

Luteal phase defect: Thought to result from problems with the secretion of progesterone, luteal phase defect causes the endometrium to be inadequately prepared for implantation of a fertilized egg. This can cause infertility or early miscarriage. Luteal phase defect may be treated with medications.

Uterine and cervical abnormalities: Uterine fibroids, scar tissue inside the uterus from previous infection or surgery, an unusual position or contour of the uterus, narrowing of the cervix, thick cervical mucous, or antibodies in the cervical mucus can all contribute to or cause infertility. Some of these problems can be treated surgically, others with medications.

Cancer treatment: Chemotherapy and radiation, especially radiation administered close to the reproductive organs, can cause infertility.  Chemotherapy sometimes causes ovarian function to diminish or puts a women a woman into early menopause. Women who are faced with cancer treatment may wish to use cryopreservation of embryos if they desire a baby in the future.  

Medications: Some medications can cause temporary infertility. These may include hormones, antibiotics, antidepressants, pain pills, and some other drugs used to treat chronic conditions.  Often, when the medication is discontinued pregnancy occurs.

Other Conditions: Other chronic medical conditions that may cause infertility include thyroid disorders, kidney disease, diabetes, Cushing's disease, HIV/AIDS, sickle cell disease, and being significantly overweight or underweight.

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Thank you so much for helping us to have our little miracle. Last year around this time I didn’t even think it was going to be possible for us to have our little baby. Here it is a year later and I’m holding him in my arms. We are truly blessed, I thank God everyday for him. After all the challenges that we have had to go through.

- Kathleen & Jim

 

 

 


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